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Sr Research Associate II, Lead Engineering and Display

Employer
GILEAD Sciences
Location
San Mateo County, CA
Closing date
Jan 27, 2023

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Job Description
We are excited to pursue the search for a highly motivated individual to join our Lead Engineering and Display (LEAD) team within Gilead's rapidly growing Protein Therapeutics Department. The successful candidate will have experience in the field of antibody discovery and protein engineering using in vitro display methods such as phage-display and yeast-display. In this laboratory-based role, the successful candidate will be involved in establishing new biotherapeutics engineering capabilities and leverage diverse methods (e.g. protein library design and construction, phage and yeast display, flow cytometry, ELISA, SPR) to support lead optimization efforts for projects across different therapeutic areas.

Responsibilities
  • Design and construct protein variant libraries for different display platforms (phage/yeast) utilizing various molecular biology techniques (cloning, PCR, gel electrophoresis).
  • Design and perform Fluorescence-activated cell sorting (FACS) and screening experiments by utilizing different FACS instruments (Sony, Cytoflex, Aria).
  • Develop new reagents and in vitro methods to access developability of proteins.
  • Conduct and analyze data from protein-protein binding assays (e.g. flow cytometry, BLI, SPR, ELISA).
  • Prepare samples for sequencing (NGS, Sanger) and analyze sequences using various software (e.g. Geneious, IGX).
  • Present results of work, interpret data, and draw conclusions regarding presented material and nature of work.
  • Help with preparation of SOPs, purchasing and management of lab consumables.

Knowledge, Experience and Skills

Applicants must have a B.S./M.S. in molecular biology, biochemistry, structural biology or a related field, with B.S. 4+ years / M.S. 2+ years of additional experience in an academic and/or industrial setting. Title commensurate with experience. An ideal candidate will have experience in most of the following areas:
  • Prior experience in one or more in-vitro protein display technologies (e.g. phage, yeast).
  • Strong background in molecular biology including molecular cloning and sequence analysis.
  • Prior experience in antibody affinity maturation and/or humanization is a plus.
  • Experience with basic bioinformatics programming (e.g. via python) is desirable.
  • Ability to work independently in individual assignments and collaboratively in team projects.
  • Strong written and oral communication skills, with the ability to manage multiple projects in parallel.
For jobs in the United States:
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.
Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, Singapore, and Hong Kong employees and contractors to receive the COVID-19 vaccines as a condition of employment. "Full vaccination" is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.

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Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.
For Current Gilead Employees and Contractors:
Please log onto your Internal Career Site to apply for this job.
Summary
  • Location: United States - California - Foster City
  • Type: Full time
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