Senior Scientist, Cellular, Genomic, and Protein Sciences

ROLE SUMMARY

As a Senior Scientist in the Cellular, Genomic, and Protein Sciences (CGPS) department, you will be at the center of our protein expression and purification operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for construct design and purification from bacterial, insect, and mammalian cells, as well as the generation and screening of mutant libraries using display technologies (yeast, phage) to generatetools and reagents to validate First in Class Targets. With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor who routinely partners with, and mentors junior colleagues within the department and across therapeutic areas. Your innovation and creativity in developing novel processes and new ideas will be frequently used to drive decision making impact across the portfolio and establish a world-leading Protein Sciences pipeline to serve a world-leading Drug Discovery pipeline.

ROLE RESPONSIBILITIES

• Represent Protein Sciences at the project team level, helping to guide new targets from gene to screen.
  
• Troubleshoot scientific and technical challenges. Mentor more junior scientists to do the same.
  
• Design constructs for expression in bacterial, insect, and mammalian cells to produce high quality recombinant proteins, protein complexes, and RNA.
  
• Design display libraries and carry out binder identification screens and use library design to produce insights into compound binding and mechanism of action.
  
• Purify and characterize recombinant proteins to enable high throughput assays, biophysical assays, and structural efforts.
  
• Prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish/patent externally.
  

BASIC QUALIFICATIONS

• PhD in Biochemistry, Structural Biology, or a related discipline with 1-2 years relevant experience in protein expression and purification, or M.S. with 7+ years of relevant experience including industry experience.
  
• Phage, yeast, or mRNA library generation and display experience for generation of binding partners, or improvement of protein characteristics.
  
• Experience in expression construct design for high-yield protein production in bacterial, insect, and mammalian cells.
  
• Demonstrated ability to purify proteins ranging from protein domains to challenging large multi-subunit and protein complexes and integral membrane proteins.
  
• Experience using Akta purification systems.
  
• Strong understanding of protein chemistry and protein analytics, including the recent scientific literature.
  
• Demonstrated ability to obtain results and drive innovative research programs independently.
  
• Strong working knowledge of the drug development process for progression of projects to identify lead compounds and/or proteins.
  
• Self-motivated, organized, and capable of working independently and in a collaborative environment.
  
• Strong oral and written communication skills.
  

Nice-to-Have

• Characterization of proteins by analytical and biophysical methods including aSEC, fSEC, DLS, DSF, SEC-MALS, and other methods to monitor conformation, oligomerization, and stability.
  
• Scientific programming or data analysis skills related to NGS analysis
  

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Candidate may periodically be asked to travel to other Pfizer sites to give presentations or attend meetings.

OTHER JOB DETAILS

Relocation Support Available
Work Location Assignment:On Premise

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development