Gene Editing SME

Cambridge, Massachusetts
Closing date
Mar 28, 2023

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Full Time
Organization Type
Jobseeker Type
  • Responsible for 1) delivery of robust high quality investigative, molecular and omics toxicology data, portfolio and regulatory support within the current gene editing and advanced gene therapy pipeline.
  • Focus will be on enabling laboratory and portfolio support for gene therapy and translational gene editing platforms within the advanced gene therapy and early gene editing pipeline with collaborations across RUs and partner lines.
  • Propose and deliver on Drug Safety R&D issue management, technology and strategic initiatives with focus on novel gene editing modalities and delivery systems.
  • Review and analysis of internal and external data in support of in vitro-in vivo or nonclinical-clinical translation in the gene therapy and gene editing platforms.
  • Effective communication and collaboration with local and global peers in DSRD, Research units and partner line

  • Primary area of focus is to be the key subject matter expert focusing on all aspects relevant to gene editing and gene therapy technologies including but not limited to nucleases, mRNA, DNA template, nanoparticles, viral vectors, next generation sequencing, on-target and off-target integration and in vitro screens.
  • Support gene editing and advanced AAV portfolio by developing modality specific development and regulatory strategies including responding to regulatory query by developing laboratory packages through partnership with investigative, molecular and omics labs.
  • Participate in issue management teams and Drug Safety Team Lead (DSTL) within gene editing and gene therapy programs in development. This will involve leading projects and/or providing leadership to junior laboratory scientists and project leaders for projects and issues from early discovery to development.
  • Delivery of robust, high-quality lab-based investigative toxicology, translational and biomarker data to support the development, validation and implementation of safety tools.
  • Leading the recommendation and presentation at governance meetings for proposing new mechanistic aspects of editing technologies and issue management.
  • Author and review protocols, reports to support regulatory submissions, to ensure scientific integrity, technical feasibility and assess resource demand
  • Responsible for developing scientific strategies to improve the overall quality of the G-DITS discipline for work conducted internally and externally.

  • PhD or equivalent experience in biology, biochemistry, toxicology, pharmacology or related fields, with 12 years experience.
  • Strong portfolio and laboratory experiences in AAV, gene editing platforms, ex vivo and in vivo delivery systems and deeper understanding of the complexities associated with therapeutic gene editing.
  • Thorough understanding of on target, off target editing, solutions to improve genome editing efficiencies in target cells and to minimize off target effects will be critical to the success of this role.
  • Ability to work in a team and mentor junior research staff.
  • Excellent oral and written communication skills to enable presentation and publication of Scientific data and results.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Additional Job Information:
  • Last Date to Apply: March 22, 2023
  • Relocation support available
  • Work Location Assignment:Flexible


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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