Senior Associate Scientist (Non-PhD) - In Vitro Global Safety Pharmacology

Role Description

This position will be responsible for supporting drug discovery by performing in vitro experiments to assess the off-target pharmacology of novel compounds using both cellular and biochemical assays. In addition the role will include performing ex vivo functional tissue bath studies.

Responsibilities

Work independently and as part of a team to help design, execute, analyze / interpret data generated from experiments ranging from in vitro cell based to functional tissue bath assays. Specific duties to include:

• Apply scientific knowledge in running early in-vitro safety screening assays (384 well plate based; medium throughput) using a range of in vitro cell based, enzyme assays and transporter assays.
  
• In addition the role is expected to grow to include performing ex vivo functional tissue bath studies and isolated Langendorff perfused heart (previous experience preferred, but not required). These assays are collectively used by research project teams to address off-target safety issues and help guide chemistry design.
  
• Keep detailed experimental records and prepare study summaries and technical reports.
  
• Have a working knowledge of analysis tools such as Excel, GraphPad, Biobook and PowerPoint for experimental documentation and data analysis/presentations.
  
• Contribute to building an innovative culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and in vitro expertise; take a proactive role in personal growth and scientific development.
  

Basic Qualifications

• Bachelor's degree plus 3 years' laboratory experience in Cell Biology, Biochemistry or Pharmacology (or related field).
  
• Previous experience running cell/enzyme based assay platforms in a medium throughput environment
  

Preferred Qualifications

• Functional ex vivo tissue bath experience (Previous experience preferred; a willingness to learn essential)
  
• Basic working knowledge of receptor pharmacology principles
  
• Strong organizational, interpersonal and communication skills as well as ability to perform tasks with minimal supervision. Team player attitude is a must.Ability to work in fast paced environment.
  
• Excellent time-management skills and ability to follow pre-established experimental designs, as well as ability to develop new protocols and methods with aptitude to troubleshoot problems in an independent manner.
  

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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