Research Associate II, Genomics Laboratory, CGR

Frederick National Laboratory for Cancer Research
Montgomery County, MD
Closing date
Oct 6, 2023
Research Associate II, Genomics Laboratory, CGR

Job ID: req3666
Employee Type: exempt full-time
Division: Clinical Research Program
Facility: Rockville: 9615 MedCtrDr
Location: 9615 Medical Center Drive, Rockville, MD 20850 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.


The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG), the world's most comprehensive cancer epidemiology research group. CGR is located at the NCI-Shady Grove campus in Rockville, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our contributions to the molecular, genetic, and epidemiologic research of the 70+ investigators in DCEG. Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG's intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. This includes the design and analysis of high throughput studies using various types of "-omics" technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis, and molecular epidemiologic studies based on novel assays focused on the metabolome and microbiome. We are seeking a research associate to join our team to support a wide range of genotyping and next-generation sequencing assays.


Within CGR, the Genomics Laboratory is a fast-paced, high throughput genotyping and sequencing facility dedicated to the support of genetic and epidemiologic studies for investigators at the National Cancer Institute. We are recruiting for a Research Associate position within the Genomics Laboratory to work as part of a team performing high-throughput SNP array and Next Generation Sequencing (NGS) experiments. Key responsibilities for the successful candidate will include:
  • Perform high throughput SNP and methylation array experiments
  • Perform NGS experiments (DNA and RNA sequencing)
  • Meet expected schedules and performance expectations in a fast-paced research laboratory environment
  • Utilize good laboratory practices and molecular biology expertise to ensure that highly sensitive assays are performed successfully
  • Follow established protocols, maintain accurate documentation, and assist with deviations and corrective actions
  • Routine maintenance, operation and troubleshooting of laboratory equipment used
  • Support a culture of continuous improvement and accountability
  • Contribute to troubleshooting of issues associated with assay processing
  • Contribute to process improvement, assay development
  • Participate in the writing and review of laboratory SOPs
  • Work collaboratively within and across teams in CGR (project management, LIMS support, technology development, quality assurance, bioinformatics) to successfully move projects forward or help integrate new approaches into routine use.


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
  • Possession of Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
  • A minimum of 5 years related biomedical experience
  • Expertise in performing, troubleshooting, or optimization of NGS, array, or other molecular biology assays
  • Strong understanding of molecular biology
  • Careful attention to detail
  • Critical thinking skills and ability to identify important variables in an experiment
  • Collaborative, team-oriented approach to solving problems and achieving goals
  • Strong organization skills, ability to multitask and manage time effectively
  • Excellent communication skills (verbal and written)
  • Working knowledge of Windows-based computer operating systems and Microsoft Office suite
  • Must be able to obtain and maintain a clearance


Candidates with these desired skills will be given preferential consideration:
  • Experience with the Illumina sequencing or array platforms
  • Experience using high-throughput laboratory equipment, such as automated liquid handlers, including use, maintenance, and troubleshooting (method development experience, expertise with Beckman Biomek or Tecan Freedom platforms a plus)
  • Familiarity with eLN and/or LIMS systems for sample and workflow tracking
  • Expertise with a wide range of specimen types and analytes used in genomics, including DNA, RNA, and FFPE-derived analytes


This position is subject to working with, or have potential for exposure to, infectious material, requiring medical clearance and immunizations.

Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.


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