Sr. Scientist, Lentiviral Vectors Upstream Early Process Development
- Employer
- Novartis
- Location
- United States
- Salary
- Competitive
- Closing date
- Sep 22, 2023
View more
- Sector
- Science, Pharmaceutical, Supply Chain, Quality Assurance
- Organization Type
- Corporate
- Jobseeker Type
- Professional
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Job Description
INTERNAL ROLE TITLE: Senior Scientist, LVV Upstream Early Process Development
LOCATION: Cambridge, MA
About this role:
The Senior Scientist, Upstream Early Process Development (USP), will be responsible for advancing scalable process development for suspension-based production of lentiviral vectors and support production of lentiviral vectors for preclinical studies and other development purposes. The candidate will participate in establishing, operating, and troubleshooting suspension shake flask and benchtop bioreactor-based cell culture processes for manufacturing of lentivirus gene therapy vectors across multiple preclinical programs and disease areas.
Key responsibilities:
• Perform hands-on cell culture expansion, transfection, and viral harvest as well as process scale-up and optimization. Support critical operations as needed in our viral production lab and deliver materials for pre-clinical and clinical studies.
• Craft and execute experiments to drive innovative technology and platform evaluation for next generation lentiviral gene therapy vectors (LVV) and work with downstream process development and analytical development teams to implement a robust process for the production of high quality LVV.
• Work with cell line development, viral characterization and formulation colleagues to develop an optimized workflow for next generation LVV manufacture and analytics.
• Provide technical support, training, and SME knowledge to assist with the development of junior associates. Expand the technical capabilities of the Process Development group by offering expertise in areas such as technology development, platform, or systems development.
• Prepare protocols, SOPs, technical reports and provide high quality data and electronic notebook documentation.
The pay range for this position at commencement of employment is expected to be between $102,400 and $153,600 / year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Diversity & Inclusion / EEO
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Minimum Requirements
Minimum requirements:
Essential requirements:
• This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will not require travel as defined by the business (domestic and/ or international). Please note that this role would not provide relocation and only local candidates will be considered.
• Minimum of a Bachelor’s Degree
• 2+ years of developing upstream process for viral vector, recombinant proteins and antibodies manufacturing and/or process development, operating suspension culture bioreactor, microbioreactor and single-use small scale stirred-tank bioreactor experiments for mammalian cell culture
• Pharma or biotech proven experience in the fields of gene therapy and/or virology
• Experience working in a BSL2+ environment
• Effective communication including presentations to convey scientific concepts to research scientists and cross-functional collaborators.
• Phenomenal teammate who demonstrates technical proficiency and creativity, collaboration and independent thought.
• Ability to work in a matrix environment.
• Strong organization
Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here:
https://talentnetwork.novartis.com/network
INTERNAL ROLE TITLE: Senior Scientist, LVV Upstream Early Process Development
LOCATION: Cambridge, MA
About this role:
The Senior Scientist, Upstream Early Process Development (USP), will be responsible for advancing scalable process development for suspension-based production of lentiviral vectors and support production of lentiviral vectors for preclinical studies and other development purposes. The candidate will participate in establishing, operating, and troubleshooting suspension shake flask and benchtop bioreactor-based cell culture processes for manufacturing of lentivirus gene therapy vectors across multiple preclinical programs and disease areas.
Key responsibilities:
• Perform hands-on cell culture expansion, transfection, and viral harvest as well as process scale-up and optimization. Support critical operations as needed in our viral production lab and deliver materials for pre-clinical and clinical studies.
• Craft and execute experiments to drive innovative technology and platform evaluation for next generation lentiviral gene therapy vectors (LVV) and work with downstream process development and analytical development teams to implement a robust process for the production of high quality LVV.
• Work with cell line development, viral characterization and formulation colleagues to develop an optimized workflow for next generation LVV manufacture and analytics.
• Provide technical support, training, and SME knowledge to assist with the development of junior associates. Expand the technical capabilities of the Process Development group by offering expertise in areas such as technology development, platform, or systems development.
• Prepare protocols, SOPs, technical reports and provide high quality data and electronic notebook documentation.
The pay range for this position at commencement of employment is expected to be between $102,400 and $153,600 / year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Diversity & Inclusion / EEO
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Minimum Requirements
Minimum requirements:
Essential requirements:
• This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will not require travel as defined by the business (domestic and/ or international). Please note that this role would not provide relocation and only local candidates will be considered.
• Minimum of a Bachelor’s Degree
• 2+ years of developing upstream process for viral vector, recombinant proteins and antibodies manufacturing and/or process development, operating suspension culture bioreactor, microbioreactor and single-use small scale stirred-tank bioreactor experiments for mammalian cell culture
• Pharma or biotech proven experience in the fields of gene therapy and/or virology
• Experience working in a BSL2+ environment
• Effective communication including presentations to convey scientific concepts to research scientists and cross-functional collaborators.
• Phenomenal teammate who demonstrates technical proficiency and creativity, collaboration and independent thought.
• Ability to work in a matrix environment.
• Strong organization
Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here:
https://talentnetwork.novartis.com/network
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