We are currently seeking a Research Associate II or Senior Research Associate, Cell Editing who will be conducting gene editing translational research within the growing Liver Tx group at Mammoth Biosciences. The successful candidate will make significant contributions to several projects within Mammoth's early-stage therapeutics pipeline. Specifically, the candidate will culture and characterize cell lines and primary hepatocytes using a variety of established methods. The candidate will receive hands-on training in the use of Mammoth's proprietary CRISPR nuclease systems for therapeutic gene editing.KEY RESPONSIBILITIES
- Gene edit cell lines and primary hepatocytes cells using Mammoth CRISPR systems
- Maintain cell lines and primary cells in tissue culture
- Characterize edited cells by genomic and biochemical techniques including ddPCR/qPCR, western blot, and flow cytometry
- Bachelor's or Master's in Biology, Chemistry, Biochemistry, Biotechnology or related discipline
- RA II: 1+ years of post graduate research experience
- SRA: 3+ years of experience or Master's with 1+ year of experience
- At least one year of industry research experience
- Experience with cell culture techniques
- Experience with standard molecular biology techniques including PCR, ddPCR or qPCR
- Experience with standard molecular phenotyping techniques including western blot, ELISA or flow cytometry
- Experience in gene editing
- Experience in culture of primary human and mouse hepatocytes
- Experience in next-generation sequencing library preparation
- A foundation in experimental documentation and data presentation
- Excellent oral and written communication skills
- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness, caregiver and ergonomics benefits
- 401(k) with company matching
Salary Range: $90,000 - $105,735
The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company's ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth's deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.