Principal Scientist, Analytical Development

Role Summary:

We are seeking a highly motivated and innovative Principal Scientist to join the Analytical Sciences Department. The primary responsibilities of the position include support of early and late-stage pipeline program deliverables and regulatory filings, analytical method development, product characterization for mAbs and ADCs, and design and execution of comparability studies. Additional responsibilities include authoring and review of technical reports and regulatory filings pertaining to characterization and comparability of products, leading product quality investigations, and providing technical leadership in support of development, qualification and troubleshooting methods spanning various analytical platforms including chromatography, capillary electrophoresis, and/or biophysical characterization. The successful candidate will show the ability to work and thrive in a highly collaborative, matrixed environment.

ROLE RESPONSIBILITIES

• Characterization of biologics or bioconjugates using relevant analytical biochemical and biophysical methods such as HPLC/UPLC chromatography, electrophoresis, UV/CD/fluorescence spectroscopy, calorimetry, and light scattering
• Mentor/Supervise other group members in either direct or matrixed reporting capacities
• Represent analytical sciences in highly collaborative groups across process sciences, manufacturing, and research
• Contribute to the implementation of technologies and strategies aimed at successful and rapid development of novel biotherapeutic modalities
• Assist junior colleagues with sample analysis, troubleshooting, data review, and instrument preventative maintenance
• Contribute to early and late phase pipeline programs through development, qualification, and transfer of analytical test methods
• Perform product characterization and analytical comparability exercises on a diverse pipeline of biotherapeutics
• Author and review of analytical technical reports, IND/BLA filings, and other regulatory submission

QUALIFICATIONS

• B.S. and 14+ years; M.S. and 11+ years; Ph.D. and 3+ years (may include post-doctoral experience) industrial experience
• Strong working knowledge of fundamental biopharmaceutical principles including an understanding of protein structure, chemistry, and degradation mechanisms
• Practical experience with biochemical and biophysical characterization methods such as SE-UPLC, CE-SDS, icIEF, LC-MS, and UV/CD/fluorescence spectroscopies
• Good work ethic, team- and project-focused, and motivated to produce high quality data within aggressive timelines
• Excellent written and oral communication skills, organization, multitasking, and demonstrated success working in a collaborative cross-functional environment

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development