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Senior Laboratory Manager - Alt Lab

Howard Hughes Medical Institute
South Boston, MA
Closing date
Feb 15, 2024

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Science, Pharmaceutical, Laboratory
Organization Type
Primary Work Address: 300 Longwood Avenue, Boston, MA, 02115
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The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biomedical research organization and philanthropy, HHMI supports a vibrant community of academic researchers, educators, students, and professionals. Together, we're unlocking the fundamentals of biology and building an open, inclusive future for science.

The lab of Dr. Frederick Alt at Boston Children's Hospital is seeking an experienced Senior Lab Manager to manage both day-to-day lab operations and vital research work. The Alt lab seeks to understand mechanisms that maintain genomic stability in mammalian cells. They research programmed genetic recombination and hypermutation processes required for the generation of the immensely diverse antibody repertoires of immune cells known as B lymphocytes. The team's current focus is the active regulation of these processes within chromatin across antibody gene loci. They also study mechanisms that promote and prevent genetic translocations that can lead to lymphoid and other cancers. More information about the lab team and their work can be found by visiting

About the Lab Manager role:
You will hold a key role - managing the day-to-day operations involved in running the lab, serving as a collaborative partner to Dr. Alt, being the primary liaison between the lab and various external partners (BCH administrative offices, HHMI science operations offices, etc.), and carrying out research focused on generating mouse models that are critical to the lab's scientific goals. The successful candidate will have strong scientific and lab management experience with a demonstrated commitment to fostering a collaborative, respectful, teamwork-oriented environment. This role would be a great fit for someone who is a self-starter, proactive, and passionate about the research work that the lab is conducting.

What we provide:
  • A competitive compensation package with comprehensive health and welfare benefits.
  • Joining the vibrant Boston Children's Hospital research community.
  • Access to HHMI's Udemy on-demand training courses and interactive skill-building seminars taught by members of our learning and organization development team.
  • Opportunities for professional development and growth.
  • Opportunities to contribute to and be listed on research publications.
  • Close collaboration with and direct mentorship from Dr. Alt.

What you'll do:

  • Carry out research projects independently.
  • Provide scientific and technical expertise to troubleshoot experiments for lab members.
  • Support other lab members' research projects by generating key reagents, modified mouse embryonic cell lines, and mouse models.

Lab Management
  • Managing the lab budget to ensure all available funds are effectively and appropriately used.
  • Coordinating equipment acquisition and maintenance processes.
  • Ordering, receiving and managing lab supply inventory
  • Writing/renewing regulatory protocols (IBC and IRB) and submitting amendments.
  • Supporting the hiring process for lab research assistants in partnership with HHMI and BCH administrative personnel.
  • Training and supervising research assistants to perform lab operations tasks.
  • Collaborating with People & Culture for various human resources duties including performance evaluations, promotions, raises, and employee relations issues.
  • Ensuring all of the lab members are trained and follow the safety guidelines.
  • Working alongside Dr. Alt to discuss, understand, and manage short-term and long-term laboratory needs.
  • Assisting Dr. Alt with the preparation of grant submissions, renewals, and progress reports.

What you bring:
  • A minimum of a bachelor's degree in life sciences is required. Applicants with graduate degrees are preferred.
  • A minimum of 6 years of experience working in an academic research laboratory with at least 3 years performing in a supervisory/lab management role.
  • Experience with budget management is required.
  • Experience with generating mouse models would be a plus.
  • Strong knowledge of Microsoft Office and relevant operational software programs.
  • Strong sense of self-motivation, integrity, trustworthiness, and demonstrated ability to work well in a diverse environment with people from a wide variety of backgrounds.
  • Passion for efficiency, operational excellence, and process improvement.
  • Ability to work independently and prioritize.
  • Ability to develop and train members of the research group.
  • Excellent verbal and written communication skills.
  • Excellent problem-solving skills and high attention to detail.
  • Excellent interpersonal, organizational, communication, and teamwork skills.

Physical Requirements:

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.

Compensation Range
$89,650.00 (minimum) - $112,000.00 (midpoint) - $145,640.00 (maximum)
Pay Type:
HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.

HHMI is an Equal Opportunity Employer

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