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Senior Principal Scientist--Proteomics and Systems Biology

La Jolla, California
Closing date
Jun 3, 2024

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Full Time
Organization Type
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At Pfizer we deliver breakthroughs that change patients' lives. The Systems Biology team plays a vital role in this mission through the identification of therapeutic targets, drug mechanisms-of-actions, and biomarkers. We are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells, and we leverage established drug discovery platforms in antibody drug conjugates (ADC), small-molecules, and bispecifics. To discover the next-generation of therapeutics, we are seeking scientific leaders with expertise in proteomics.


You and your research team will drive a deeper understanding of tumor-associated antigens, ADCs including novel payloads, and immune engagers. Relevant proteomic methodologies include high throughput mass spectrometry, data-independent acquisition (DIA), small-molecule target engagement, and profiling protein abundance, turnover, and interactomes.

You will represent the Systems Biology group on research and drug discovery teams, and will work closely with line leads in target validation, chemical biology, drug design, and biology groups to innovate and develop first-in-class oncology therapies.

  • Lead a proteomics team including identifying and prioritizing projects, developing new technologies, and mentoring junior colleagues.
  • Drive innovation in all aspects of laboratory operations including mass spec technology evaluation, proteomic software evaluation, development of quantitative sample preparation methods and peptide separation methods, data analysis and interpretation.
  • Actively contribute to project teams, department operations, and drug discovery and translational strategy.
  • Enhance the external reputation of Pfizer's Systems Biology through establish research collaborations, presenting at conferences, and contributing publications.


  • Ph.D. in Biological Sciences, Proteomics, Chemical Biology, Analytical Chemistry, or a related field
  • 6+ years relevant postdoctoral and/or industry R&D/drug discovery experience
  • Experience with label-free quantification, targeted mass spectrometry, and data independent acquisition (DIA) methods
  • Applied mass spectrometry-based proteomics experience including experience with Sciex ZenoTOF and/or Thermo Tribrid Orbitraps
  • Experience leading a small team
  • Strong oral and written communication skills

  • 10+ years of postdoctoral and/or industry R&D experience.
  • Deep understanding of automated sample prep, chemoproteomics, targeted biologics, and small-molecule degraders.
  • Knowledge on oncology including cytotoxins, kinase inhibitors, molecular glues, CD3 bispecifics, and immune-oncology.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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