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Director, In Vivo Pharmacology ADC Lead

Bothell, Washington
Closing date
Jun 24, 2024

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Full Time
Organization Type
Jobseeker Type

As a member of our Oncology Research Unit (ORU) In Vivo Pharmacology and Project Leadership group, you will lead a group focused on developing and implementing in vivo strategies to support project teams thst evaluate new drug candidates, define mechanisms and identify new targets in the area of utilizing ADC technologies. You will also play a role in leading department initiatives and strategy to identify and validate novel models and techniques that enable us to more accurately recapitulate human disease and serve as a subject matter expert across ORU in the area of in vivo modeling.

You will directly supervise laboratory staff that make up an in vivo team and work with cross functional partners to manage resource assignment to enable portfolio progression.

You will participate in pre-clinical drug discovery and development projects with a focus on application of ADC technologies while also contributing to projects utilizing other technology platforms such as small molecules and alternative biologics. This will be done through close partnership with cross functional leadership and project teams to design, plan and execute an in vivo strategy to ensure efficient and effective project decision-making. You will also be a key contributor to the In Vivo Committee, responsible for contributing to peer review of protocols and presenting study plans and obtaining peer input for protocol finalization and approval to meet research project. You will provide technical and scientific expertise in in vivo pharmacology across ORD to enable target identification, validation, prioritization and efficient drug discovery.

  • Lead a team of up to 15 in vivo scientists including PhD level.
  • Manage appropriate resourcing and prioritization efforts of sub-teams within the ADC in vivo group to ensure optimal portfolio progression and scientific rigor.
  • Provide supervision and mentorship of individuals in team to enable delivery of in vivo strategy and data to enhance our ability to accurately identify targets and drug candidates with high potential for success in the clinic - includes generating data to support efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Develop strategy for Translational Pharmacology ADC team to more accurately model oncology indications of strategic priority using in vivo systems.
  • Contribute to overall strategy across the department to strengthen the ability to model disease and efficiently leverage expertise and resource and enable a "one team" culture.
  • Serve as the in vivo pharmacology lead for several drug discovery projects.
  • Mentor individuals to develop and characterize new in vivo mouse models to study biologic mechanisms and support exploration of novel cancer therapeutics.
  • Provide interpretation of model systems in the context of clinical translatability.
  • Drive innovation through internal and external capabilities and collaborations
  • Generate and be accountable for the necessary Animal Use Protocols that ensures team members comply with all regulatory requirements and internal policies.
  • Contribute to relevant in vivo sections of study reports and regulatory documents, e.g., IND filings.
  • Ensure that projects have all critical in vivo data to enable project stage dependent decisions. Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

  • Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or related discipline
  • Minimum 10 years post Ph.D. related oncology or immuno-oncology experience in industry
  • Supervisory, mentoring and leadership experience
  • Demonstrated track record in collaborative research in Oncology drug discovery programs in particular in the ADC field.
  • Expertise in animal models of human cancers
  • Hands on in vivo (eg: IV, PO dosing, blood/tissue collection) and ex vivo skills (flow cytometry, western blot, ELISA)
  • Excellent written and oral communication and presentation skills
  • Proficiency with all common office and scientific software

  • Industry experience with technical and scientific experience in drug discovery and preclinical development
  • Expertise with GEMM and humanized models
  • Strong track record of scientific accomplishments in industry as evidenced by publications or other equivalent achievements
  • Experience getting results through creativity and unique problem solving

  • Must be willing and able to work after hours as needed to ensure study integrity

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Work Location Assignment:On Premise

The annual base salary for this position ranges from $161,600.00 to $269,400.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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