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Research Associate - Preclinical Team

Employer
Gladstone Institutes
Location
San Bruno, CA
Closing date
May 26, 2024

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Category:Science
Lab/Area:Marson Lab

Description:

Who we are:

The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medical research and education in neuroscience, cardiovascular biology, immunology, and stem cell biology. Home to notable leaders in science and biomedicine, Gladstone comprises five institutes as well as various centers and programs. All of its approximately 600 members are aligned in their mission to carry out or support science that overcomes disease. Located in an award-winning building at the Mission Bay Campus, Gladstone offers a competitive salary and benefits program. It provides an ideal environment for those seeking to maximize and fully leverage their potential. Consider Gladstone and make a difference in human health.

About the role:

The Gladstone-UCSF Institute of Genomic Immunology is recruiting a Research Associate (RA) to perform in vivo experiments in mouse models of immunotherapies for ongoing multidisciplinary cellular engineering projects. Our institute has pioneered the application of novel genetic engineering technologies such as CRISPR to primary human immune cells. These new technical abilities have furthered our research into the genetic control of T cell biology as well as opened the door to novel cancer immunotherapies based on engineered human immune cells. This individual would be part of a preclinical research team under the direction of Justin Eyquem (UCSF) streamlining the generation, benchmarking, and functional assessment of genetically engineered human T cell therapies for cancer and inflammatory disease.

What you will do:
  • The RA will be trained in experimental procedures involving mouse models of cancer and autoimmune disease and participate in rigorous assessments of the in vivo efficacy of T-cell therapies in these models. Tasks require routine handling of mice.
  • Perform routine mouse colony management duties (ear punching/ear tagging/tailing for genotyping, weaning, aging and sexing of pups, and euthanasia, et al).
  • Identify and implement required care for mice with health issues and mice on special treatment (special diet, fasting, treated water).
  • Learn and become proficient with techniques related to cancer models, such as intravenous injections of cancer cell lines and/or immune cells by tail vein injection or retro-orbital injection; administer medication/reagents orally or via IV, IP, IM, or subQ.
  • Learn and become proficient with in vivo imaging (bioluminescence) and other tumor assessment techniques.
  • Learn and become proficient with tissue collection and processing, e.g. blood, spleen, lymph nodes, engrafted tumors, or other tissues of interest for downstream analysis.
  • Maintain mouse database using Google Sheets or mouse colony software.
  • Genotyping via PCR followed by electrophoresis or Sanger sequencing.
  • Place genotyping orders in TransnetYX and interpret the genotyping results.
  • Maintain and ensure a safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols.
  • Other related duties as assigned


What you will need:
  • BA/BS degree and one or more years of laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience
  • Must be able to work with mouse colonies
  • Experience with general laboratory techniques, especially basic vivarium techniques (mouse handling, injection, digestions). Molecular and cellular biology techniques are preferred (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis)
  • Excellent attention to detail, organizational and interpersonal communication skills (verbal and written)
  • Willingness and ability to learn new methods and skills for changing research priorities
  • Ability to work independently and as a member of a research team
  • Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines
  • Ability to comply with policies and procedures
  • Some evening and weekend hours are required


What is preferred:
  • Prior experience with mammalian cell culture, especially T cell culture
  • Prior experience with immunotherapy studies in animal models


If this role is not for you:

Please stay in touch and to see a complete list of our open career opportunities, please visit:

https://gladstone.org/careers

Hiring Range:

Hiring Range:

RA I $25-$29/hr
RA II $66,560- $78,306K

Gladstone Perks & Benefits
  • People -work with talented, committed, and supportive teammates within an organization that values each member of its community.
  • A meaningful place to grow and learn -whether it's your professional skills or scientific knowledge, we have the resources and environment to advance either so you can better support Gladstone's mission to drive a new era of discovery in disease-oriented science and to mentor tomorrow's leaders in an inspiring and diverse environment.
  • Healthy work/life balance -you are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work.
  • Compensation -competitive salary. Title and salary will be commensurate with education and experience.
  • Excellent benefits -generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.

Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, sex, religion, national origin, ancestry, age, marital status, medical condition, physical or mental disability, veteran status, sexual orientation, or any other non-job related characteristic. We make all employment decisions so as to further this principle of equal employment.

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