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Senior Scientist - Prostate Cancer Biology

La Jolla, California
Closing date
May 16, 2024

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Full Time
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing transformative medicines to patients around the world.

What You Will Achieve

Pfizer's Oncology Research Unit (ORU) in La Jolla, California is seeking a highly motivated and experienced individual with a background in hormone-driven cancers to join a dynamic and fast-paced discovery biology team. The successful candidate will join the Oncogene & Cancer Vulnerabilities group embedded within the Cancer Cell Biology division to support our collective efforts to discover and target drivers of prostate cancer disease progression. This is a lab-based position with a focus on designing and executing molecular and cellular-based assays as well as mentoring junior colleagues. The ideal candidate is a team player, has familiarity with prostate cancer disease biology, and a demonstrated track record of advancing innovative ideas into tangible assets. This individual will thrive in a matrixed environment with ample opportunities for personal growth and development.

How You Will Achieve It

  • Design, execute, and analyze experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to prostate cancer etiology.
  • Apply strong attention to detail in experimental design, execution, and interpretation.
  • Actively partake in scientific discussions and be informed of recent publications and advancements.
  • "Lead from the bench" by mentoring junior colleagues.
  • Contribute to a culture that values teamwork, collegiality, accountability, and continued learning and growth.



  • PhD degree in tumor/cancer cell biology, with 2+ years of post-doc or industry experience in the field of prostate cancer.
  • Track record of advancing independent research, evidenced by at least 1 first-author publication in a peer reviewed journal and presentations at an internationally recognized conference series.
  • Strong proficiency with foundational cell and molecular biology techniques; for example: construct design, stable cell line generation, qRT-PCR, Western blotting, ELISA, IP/ChIP, 2D and 3D proliferation assays.
  • Familiarity with human organoid cultures, CRISPR-mediated gene editing, NGS sample prep, complementation assays (NanoBRET/NanoBiT), and flow cytometry.
  • Outstanding organizational, communication, writing, and presentation skills.


  • Proficiency in integration of molecular profiling data including transcriptomic, proteomic, and genomic datasets.
  • Experience using R programming language for interpretation of large multi-omic data sets.


• Standing, sitting, bending, lifting, walking in a laboratory setting.

• Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory.

• Standard business office conditions; sitting, standing as appropriate.


May require weekend work, as needed.

Additional Information:
  • Relocation support available
  • Eligible for Employee Referral
  • Work Location Assignment:On Premise
  • Last Day to Apply: May 14, 2024

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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