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NMR Scientist III

Employer
Frederick National Laboratory for Cancer Research
Location
Hood College, MD
Closing date
Jun 20, 2024

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Sector
Science
Organization Type
Corporate
NMR Scientist III

Job ID: req3958
Employee Type: exempt full-time
Division: Basic Science Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Basic Science Program (BSP) pursues independent, multidisciplinary research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics. Research efforts are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR).The Macromolecular Nuclear Magnetic Resonance (MNMR) Facility for Biological Research is a part of the Center for Structural Biology (CSB) in NCI at Frederick. The MNMR Facility operates six NMR spectrometers with proton resonance frequencies from 850 to 500 MHz. Four of the highest field spectrometers (850, 800, 700, 600) are equipped with helium cooled cryoprobes optimized for high-resolution experiments on biological samples in solutions. The second 600 MHz spectrometer is set up as reconfigurable development system with multiple probes allowing for high-resolution liquid state as well as biosolids Magic Angle Spinning (MAS) experiments. The 500 MHz spectrometer is equipped with broadband X-H/F type nitrogen cooled cryoprobe which is optimized for work on small molecule samples and serves as an analytical tool for many users.

KEY ROLES/RESPONSIBILITIES

The MNMR facility manager will be responsible for performing following tasks.
  • Perform helium fills on non-pumped and pumped NMR magnets.
  • Perform nitrogen fills for NMR magnets.
  • Monitor consumption of cryogens and place orders for refills.
  • Perform maintenance of NMR consoles and install upgrades.
  • Perform maintenance of NMR probes and benchmark measurements.
  • Troubleshoot problems with NMR consoles and probes.
  • Update and troubleshoot Topspin and other NMR related software.
  • Maintain Linux computers which operate NMR consoles.
  • Work with NCI/CCR IT engineers for Linux OS updates and network connections.
  • Provide user trainings on basic NMR hardware and software.

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
  • Possession of a PhD degree in electrical engineering, physics, or chemistry from an accredited college or university according to the Council for Higher Education Accreditation (CHEA. Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the education requirement, a minimum of five (5) years of experience managing a NMR facility or maintaining multiple NMR magnets and consoles.
  • Master class knowledge of engineering of NMR consoles and probes.
  • High level ability to use Topspin software and tailor pulse programs and parameters upon requirement of users.
  • Ability to run canonical NMR experiments for protein and nucleic acids.
  • Properly trained for handling cryogen including Helium and Nitrogen.
  • Ability to travel as needed for business purposes.
  • Ability to obtain and maintain a security clearance.

Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

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