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Principal Scientist, ADC Chemistry

Bothell, Washington
Closing date
Jun 24, 2024

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Full Time
Organization Type
Jobseeker Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The ADC Chemistry (AC) group is seeking a highly motivated, creative, and experienced synthetic chemist to develop novel payloads for antibody-drug conjugates (ADCs). You will apply organic synthesis and medicinal chemistry to development of new anticancer therapies. Your background in structure-based drug discovery and project leadership are critical for this position. You will work collaboratively within the chemistry department and with researchers across the biology, computational, and translational sciences to advance oncology therapeutics from concept to clinic.

How You Will Achieve It

  • Utilize experience and creativity in synthetic and medicinal chemistry to advance ADC technology
  • Design novel payloads using computational chemistry and structural biology
  • Execute efficient routes for complex ADC payloads and drug linkers
  • Interpret SAR and prioritize compounds for in vitro and in vivo biology assessment
  • Contribute to and lead programs by executing lead optimization strategies and driving discovery goals
  • Effectively communicate and collaborate across a diverse research department to advance preclinical projects
  • Prepare patent applications and publish impactful research
  • Mentor and manage internal teams for high performance and scientific growth
  • Expand the capabilities of chemistry department by implementing new techniques and molecular design and implement cutting-edge technologies



  • Ph.D. degree in Organic/Medicinal Chemistry or related area of science with minimum 3 years related medicinal chemistry experience in the biopharmaceutical industry OR
  • M.S. degree in Organic/Medicinal Chemistry or related area of science with minimum 7 years related medicinal chemistry experience in the biopharmaceutical industry OR
  • B.S. degree in Organic/Medicinal Chemistry or related area of science with minimum 9 years related medicinal chemistry experience in the biopharmaceutical industry
  • Contemporary knowledge of the key Medicinal Chemistry concepts and design tools required for pharmaceutical drug discovery


  • Track record of accomplishment in the biopharmaceutical industry, with examples of high impact publications from scientific work to date
  • Experience leading a medicinal chemistry team
  • Experience working in matrix teams of scientists to deliver defined objectives


Lift 10 lbs

Additional Information:
  • Relocation Assistance Available
  • Eligible for Employee Referral
  • Work Location: On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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