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Senior Principal Scientist - ADC Chemistry

Bothell, Washington
Closing date
Jun 26, 2024

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Full Time
Organization Type
Jobseeker Type
Role Summary

The ADC Chemistry (AC) group is seeking a highly motivated, creative, and experienced medicinal chemist to develop novel payloads for antibody-drug conjugates (ADCs). You will apply your background in drug development, medicinal chemistry, and organic synthesis to develop new anticancer therapies. Your background in structure-based drug discovery and project leadership are critical for this position. You will work collaboratively within the chemistry department and researchers across the biology, computational, and translational sciences. You will play a vital role as scientific leader and key contributor to large, multi-disciplinary, matrix teams from project inception to delivery of clinical drug candidates.

Key Responsibilities
  • Drive a strong scientific agenda, apply expert data analysis, and contemporary design tools to drive effective target design and prioritization within a portfolio of projects
  • Contribute to ADC payload strategy and utilize experience in synthetic chemistry and methodology to execute and optimize routes to complex payloads and drug linkers
  • Utilize state-of-the-art computational chemistry and structural biology to advance the design of ADC technology
  • Effectively communicate and collaborate across a diverse research department and outside functions, such as Drug Safety, to efficiently advance preclinical projects
  • Mentor and manage teams directly or in a matrix format for high performance and scientific growth
  • Expand the capabilities of chemistry department by implementing new techniques and molecular design and implement cutting-edge technologies
  • Prepare patent applications, publish impactful research, and present externally at leading conferences

Basic Qualifications
  • Ph.D. degree in Organic/Medicinal Chemistry or related area of science with minimum 5 years related medicinal chemistry experience in the biopharmaceutical industry OR
  • M.S. degree in Organic/Medicinal Chemistry or related area of science with minimum 9 years related medicinal chemistry experience in the biopharmaceutical industry OR
  • B.S. degree in Organic/Medicinal Chemistry or related area of science with minimum 11 years related medicinal chemistry experience in the biopharmaceutical industry
  • Strong track record of accomplishment in the biopharmaceutical industry
  • Expert working knowledge of the key medicinal chemistry concepts and design tools required for pharmaceutical drug discovery
  • Consistent record of peer-reviewed publications from scientific work to date

Preferred Qualifications
  • Experience leading matrix teams of scientists to deliver defined project objectives
  • Examples of high impact publications or presentations in the drug discovery or ADC field

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


Lift 10 lbs

Additional Information:
  • Relocation support available
  • Eligible for employee referral
  • Work Location Assignment:On Premise

The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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