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Co-Director (Assistant/Associate Research Professor) - Cryo-EM Facility

Penn State University
University Park, PA
Closing date
Jun 21, 2024

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Organization Type

* CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, apply internally through Workday.

* CURRENT PENN STATE STUDENT (not employed previously at the university) and seeking employment with Penn State, please login to Workday to complete the student application process. Please do not apply here, apply internally through Workday.

* If you are NOT a current employee or student, please click "Apply" and complete the application process for external applicants.


The Huck Institutes of the Life Sciences at Penn State University is seeking applications for a non-tenure track faculty at the rank of Assistant/Associate Research Professor to co-direct our Cryo-Electron Microscopy Facility.

The successful candidate will be a Ph.D. trained scientist with exceptional hands-on experience of all aspects of Cryo-EM.


* Ensure the safe running of the Cryo-EM facility. Implement and monitor health and safety processes, develop lab protocols, and risk assessments.
* Lead on the strategic and operational management of the Cryo-EM facility.
* Operate Titan Krios and Talos Arctica transmission electron microscopes for cryo-EM data collection and maintenance of these microscopes by communicating with ThermoFisher Scientific service team.
* Operate and maintenance of equipment for cryo-EM specimen preparation.
* Train Penn State cryo-EM users to operate equipment for cryo-EM specimen preparation and cryo-EM data collection.
* Support and interact with other researchers and faculty members at Penn State to enable macromolecular structure determination by cryo-EM in support of their various projects.
* Analyze cryo-EM data collections including contrast transfer function estimation, particle picking through neural network algorithms, frame alignment, 2D classification, 3D ab-initio reconstructions, 3D classification through heterogeneous refinement, homogeneous refinement, masked local refinement, particle polishing, and 3D variability.
* Train and mentor researchers in cryo-EM data processing using various state-of-the-art software for 3D reconstructions and atomic model building, and in the fundamentals of cryo-EM sample handling and preparation.
* Provide consultancy services to researchers in the field of life science, assisting them in implementing the optimal structural biology solutions.
* Possess the potential to establish collaboration with fellow researchers in the field of life science and actively contribute to the development of grant proposals and funding applications.
* Initiate collaboration with external researchers from both academy and industry who are interested in using cryo-EM to solve high-resolution structures of macromolecules.


* Ph.D. in structural biology or a related field
* Experience in cryo-EM structural biology with a demonstrated track record
* Extensive experience and a strong understanding in cryo-EM field from specimen preparation, data collection to analysis and solving cryo-EM high-resolution structure
* Proficient in the use of a transmission electron microscope (equipped with an autoloader and direct electron detector) and ability to complete independently microscope direct alignments for high quality data acquisition
* Experience in using EPU for data collection for cryo-EM single particle analysis
* Experience in specimen preparation, and collecting and processing cryo-electron tomography (cryo-ET) data is desirable.
* Experience in specimen preparation, and collecting and processing microcrystal electron diffraction (MicroED) is desirable.
* Expertise with all related softwares (cryoSPARC, Relion, EMAN2, ChimeraX, ISOLDE, Coot, Phenix, ccp-EM, ccp4-suite)
* Experience in molecular modeling, docking and MD simulations using AMBER
* Experience in other biophysical techniques is desirable
* Teaching experience is a plus
* Ability to work as part of a team and excellent communication skills

Application: To be considered, please include in your cover letter a summary of relevant experience and provide a CV, contact information for two professional references (name, position title, phone number, and e-mail address). Review of applications will begin immediately and continue until filled.

This is a limited-term appointment funded for one year from date of hire with excellent possibility of renewal.

The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms. We embrace individual uniqueness, foster a culture of inclusion that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusion as a core strength and an essential element of our public service mission.

Penn State offers competitive benefits to full-time employees, including medical, dental, vision, and retirement plans, in addition to tuition discounts (75% discount for spouse and children), and paid holidays. Please visit for more detailed information.


Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act and the Pennsylvania Act of 1988, Penn State publishes a combined Annual Security and Annual Fire Safety Report (ASR). The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters. The ASR is available for review here.

Employment with the University will require successful completion of background check(s) in accordance with University policies.


Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact 814-865-1473.

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University Park, PA

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