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Principal Scientist/In Vivo Lead--Oncology

Bothell, Washington
Closing date
Jul 28, 2024

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Full Time
Organization Type
Jobseeker Type

You will participate in pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. You will be responsible for working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision-making. You will also be a key contributor to the In Vivo Committee, responsible for presenting study plans and obtaining peer input for protocol finalization and approval to meet research project objectives. You will directly supervise laboratory staff that make up an in vivo team responsible for study performance and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in in vivo pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization and efficient drug discovery.

  • Collaborate across project teams to establish scientific in vivo strategy and study plans for drug discovery projects.
  • Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
  • Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.
  • Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Supervise and guide a small team of scientists
  • Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
  • Ensure team members comply with all regulatory requirements and internal policies.
  • Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary.
  • Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment.
  • Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings.
  • Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.


  • Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or a related discipline
  • Minimum 5 years industry experience including technical and scientific experience in drug discovery and preclinical development.
  • Experience in collaborative research in Oncology drug discovery programs.
  • Experience with animal models of human cancers
  • Hands on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).
  • Experience supervising a small team of Scientists
  • Excellent written and oral communication and presentation skills
  • Proficiency with all common office and scientific software

  • Strong track record of publications or evidence of equivalent achievements in industry
  • Experience with GEMM and humanized models


Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis


Must be willing and able to work after hours as needed to ensure study integrity

Relocation support available

Work Location Assignment:On premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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