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Principal Scientist- Particle Characterization

Groton, Connecticut
Closing date
Jul 26, 2024

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Full Time
Organization Type
Jobseeker Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a highly skilled and motivated Principal Scientist on our Particle Characterization Team, you will be pivotal to our operations, embodying our steadfast dedication to quality in everything we do daily. Your recognition as a technical expert and a major scientific contributor is assured. Your extensive knowledge of particle characterization will be invaluable to our developmental projects, and you will adeptly represent the team in multidisciplinary settings. Your innovative scientific approach will be instrumental in propelling Pfizer towards new achievements and aiding patients worldwide.

How You Will Achieve It

The Principal Scientist is tasked with leading characterization activities for pharmaceutical drug substances, intermediates and drug products, creation of methods and authoring sections of regulatory submissions.

This role supports multidisciplinary project teams, working with colleagues to define and execute particle characterization activities for drug substances or intermediates, in line with project timelines. The position involves conducting physical characterizations of pharmaceutically relevant powders, including assessments of particle size and shape.

Responsibilities include developing and implementing sophisticated analytical methods to characterize particles in pharmaceutical products.

The ideal candidate will possess a robust background in particle analysis, outstanding problem-solving abilities, and a dedication to innovation and lifelong learning. The role will also encompass collaborating with cross-functional teams to ensure product quality and safety, employing state-of-the-art technology for data analysis and interpretation, and conducting experiments to identify and address potential issues. The role requires regular monitoring and maintenance of particle analysis equipment, staying abreast of industry developments to integrate new analytical techniques, and effectively communicating findings to the team, stakeholders, and upper management.

Additionally, the Principal Scientist will train and guide junior scientists in particle analysis methods, ensure adherence to regulatory standards, participate in R&D to enhance analytical techniques, contribute to validation protocol development, and collaborate with external entities for support and expertise.

The role also involves assisting in the resolution of technical challenges related to particle analysis.


  • Ph.D. in Analytical Chemistry or a related field with over three years of R&D experience, a M.S. with 9 years, or B.S. with over 10 years of experience.
  • Expertise in particle characterization, including particle size analysis for pharmaceutical substances and products.
  • An in-depth understanding of particle size analysis techniques such as laser diffraction and optical imaging, along with the ability to employ these methods and instruct others.
  • Comprehensive knowledge of the physical and particle properties required for the manufacture of drug substances and the materials needed for drug product formulation is important.
  • A proven track record of robust technical skills and proficiency in the development, validation, transfer, and troubleshooting of analytical methods.
  • The demonstrated capability to acquire new techniques and resolve complex analytical challenges
  • The ability to adhere to timelines and collaborate with multidisciplinary teams is crucial.
  • Outstanding interpersonal skills and proven leadership qualities, such as the ability to influence and work collaboratively with peers, mentor and coach others, and provide oversight and guidance for colleagues' work,
  • Proven oral and written communication abilities, including data visualization, delivering presentations, and writing technical articles.

  • Experience in solid-state characterization, encompassing X-ray powderdiffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, NMR, among others. Proficient in a variety of general analytical techniques.
  • Proficiency in a broad range of software and information systems, including electronic notebooks
  • A strong interest and eagerness to learn new technologies and concepts

  • Ability to perform mathematical calculations and ability to perform complex data analysis

Other Job Details
  • Relocation support available
  • Work Location Assignment:On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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