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Lab Manager / Research Associate in Genomics and Heart Disease

Employer
Stanford University
Location
Stanford, CA
Closing date
Jul 14, 2024
We are seeking a highly motivated and organized individual to join us as a Lab Manager and Research Associate in Genomics and Heart Disease. In this role, the candidate will support three interrelated laboratories (Jesse Engreitz, Casey Gifford, and Xiaojie Qiu) in the Stanford Children's Heart Center Basic Science and Engineering Initiative and Department of Genetics, which are all located together in the Biomedical Innovations Building on Stanford main campus.

Lab overview: Our overall mission is to leverage advances in genetics and genomics to cure children's heart diseases. In particular, DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions - if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al. Nat Genet 2019, Nasser et al. Nature 2021), and applied these and other approaches to understand the genetic basis of congenital heart defects (Gifford et al. Science 2019, Schricker et al. Nature 2019, Ameen et al. bioRxiv 2022). We have now identified enhancers that contain disease variants that affect risk for congenital heart defects, and aim to study the functions of these enhancers in mouse models and human cardiac organoids. These studies will ultimately help to uncover biological mechanisms of congenital heart defects, and help to guide diagnosis and treatment for children with heart disease. For information and recent work, see https://www.caseygiffordlab.com, https://www.engreitzlab.org, and https://med.stanford.edu/base.html.

We are looking for a creative and passionate person at any stage in their career to lead management of our combined experimental/computational laboratory. The Gifford, Engreitz, and Qiu Laboratories are located adjacent to one another and provide a dynamic, interdisciplinary workplace with unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems.

The candidate for this position should have hands-on experience in molecular biology, genomics, and cellular assay development; excellent organization, problem-solving, interpersonal, and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients. Candidates with or without prior laboratory management experience are welcome to apply. On-the-job training will be provided.

In addition to submitting your application via the Stanford web portal, please email your CV and cover letter directly to Profs. Casey Gifford (caseygifford@stanford.edu) and Jesse Engreitz (engreitz@stanford.edu).

Duties include:
  • Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease
  • Together with PIs, oversee lab management including protocols, procedures, inventory, and training
  • Develop and apply functional genomics techniques, including epigenomics, single-cell, imaging, and CRISPR-based assays in human cells and/or in vivo models of disease
  • Train, mentor, and/or supervise lab members in experimental techniques, scientific design, and laboratory safety protocols
  • Collaborate with a team of experimentalists and computational biologists
  • Create scientifically rigorous visualizations, communications, and presentations of results
  • Contribute to generation of protocols, publications, and intellectual property
  • Coordinate ordering for all lab members and maintain a database to manage these orders. Ensure orders are placed and delivered in a timely manner
  • Assist with budgeting and financial overviews, including compiling and reporting purchasing data and streamlining inventory and costs
  • Develop organizational tools to improve productivity of lab
  • Maintain and update laboratory protocols
  • Oversee lab safety compliance and communicate with safety committees and groups, as well as participate in lab inspections.
  • Coordinate the repair, evaluation, service contracts, calendar system, and annual certifications of lab equipment.
  • Maintain a current chemical inventory.
  • Oversee the maintenance of cold storage units, including liquid nitrogen.

* - Other duties may also be assigned.

DESIRED QUALIFICATIONS:
  • B.S. in Biology, Biochemistry, Biophysics, Genetics, or related life science field. Highly motivated candidates of all levels are encouraged to apply.
  • Hands-on experience in molecular biology or genomics
  • Experience with quantitative data analysis, CRISPR, and/or single-cell methods a plus
  • Curiosity in research and creativity in problem-solving
  • A great team member with strong interpersonal and collaboration skills
  • Previous leadership or lab management experience a plus
  • Outstanding verbal and written communication abilities
  • Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
  • A passion for science and sense of urgency to find new medicines to benefit patients


EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
  • Comprehensive understanding of scientific principles.
  • General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
  • Strong analytical skills and excellent judgment.
  • Ability to maintain detailed records of experiments and outcomes.
  • Ability to work under deadlines with general guidance is essential.
  • Excellent organizational skills and demonstrated ability to accurately complete detailed work.


CERTIFICATIONS & LICENSES: None.

PHYSICAL REQUIREMENTS*:
  • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
  • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
  • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
  • Must have correctible vision to perform duties of the job.
  • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
  • Ability to lift heavy objects weighing up to 50 pounds.
  • Ability to work in a dusty, dirty, and odorous environment.
  • Position may require repetitive motion.

*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:
  • May require working in close proximity to blood borne pathogens.
  • May require work in an environment where animals are used for teaching and research.
  • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
  • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
  • May require extended or unusual work hours based on research requirements and business needs.


The expected pay range for this position is $71,000 to $88,000 per annum. Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.

WORK STANDARDS (from JDL):
  • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
  • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
  • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.

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