Research Fellow in Chemical Biology

Are you an ambitious researcher looking for your next challenge?

Do you have an established background in organic chemistry and chemical biology?

Do you want to further your career in one of the UK's leading research intensive Universities?

We are looking for an outstanding Research Associate to work on our EPSRC-funded project Chemical probes to decode the subcellular redox-regulated proteome with Dr Megan Wright in the School of Chemistry and the Astbury Centre for Structural Molecular Biology. The aim of the project is to develop new small molecule tools that can be used to label proteins in a time- and spatially-controlled manner inside living cells. This will allow us to investigate redox signalling, a mechanism used by cells to regulate essential cellular processes such as division and growth, but whose dysregulation is linked to diseases and ageing. Within the role, you will develop chemical probes as well as methods to analyse and apply these tools in biological samples. You will demonstrate the power of your new tools by studying redox processes in plant cells, in collaboration with Professor Alison Baker and Professor Christine Foyer in the Faculty of Biological Sciences, and in human cell lines. This position will provide technical training in interdisciplinary science, and tailored opportunities to support your professional development - for example in grant writing, teaching/mentoring and networking. Experience of synthetic chemistry and of research at the interface of chemistry and biology are essential. Training can be provided in all other required specific techniques (cell culture, biochemical methods and proteomics).

To explore the post further or for any queries you may have, please contact: Dr Megan Wright, University Academic Fellow in Chemical Proteomics Tel: +44 (0)113 343 3196, email: M.H.Wright@leeds.ac.uk