Postdoc in Interdisciplinary Laboratory of Biological Systems Modelling

Location
Poland
Posted
Aug 14, 2019
Closes
Sep 13, 2019
Ref
116995
Organization Type
University and College
Hours
Full Time
Description of the position

Title of the project: Mysteries of entanglement - proteins, life and physics

Project description: The goal of this project is to develop new methods to apply experimental data from NMR and optical traps to expand our knowledge of proteins with non-trivial topology. Currently it is still not known how to untie experimentally knotted proteins by chemical or thermal denaturation. Therefore our goal is to determine their function and the folding process (the free energy landscape) through the single molecule level approach (AFM, optical traps). Moreover, to fully understand these exotic structures, their degradation in proteasome will be investigated via the NMR (in deuterated water). The role of applicant will be to include these data into computational study. Thus, through the use of multiscale computational methods, we will investigate on one hand the conformational stability, the strength of the internal interactions, as well as routes to tie/untie proteins, and on the other hand we will use state-of-the-art methods to take into account non-trivial topology of investigated proteins. In this work we will use a combined coarse grain and explicate solvent molecular dynamics / replica exchange approaches and statistical mechanics methods to determine unbiased landscape of proteins with non-trivial topology.

Requirements

The successful post-doc candidate will have a PhD degree in physics/chemistry or related discipline, very good experience in conducting molecular modeling, multiscaling modeling. Experience with high-performance computing, knowledge of Python and scientific computing libraries and Linux environment is necessary. Although not required, any previous experience in investigation of proteins on the single molecule level would be welcome. Scientific achievements confirming the qualifications will be required (at least two significant publications after finishing PhD studies or a previous post-doc). PhD should be obtained no sooner than 7 years before the starting year of the employment in the project.

We offer

An opportunity to participate in a multidisciplinary project in one of the best scientific institutions in Poland. Stimulating, young and friendly work environment. Access to high-end computing equipment (CPU clusters). Opportunity to participate in COST network and various EMBO workshops.

How to apply?

Required documents:

Two letters of recommendation, a copy of a PhD certificate (PhD obtained no sooner than 7 years before the starting year of the employment in the project), short CV (up to two A4 pages), motivation letter.

Other

Keywords: proteins with unusual topology, nodes, NMR, AFM, evolution, thermodynamics of protein-inhibitor interaction

Salary: 8000-10000 PLN

Maximum period of contract/stipend: 36

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